Study the Possible Protective and Therapeutic Influence of Coriander (Coriandrum sativum L

Several studies reported many neurodegenerative disorders and Alzheimer' disease induced by aluminum chloride on cerebral cortex of male rats. Coriander (Coriandrum sativum) is a plant among others which improve blood circulation to the head, impart mental concentration and memory capabilities. Coriander, both its leaves and its seeds are grown as spice group all over the world. The present investigation aims to clarify the role of coriander seed aqueous extract as a protective and therapeutic agent against neurodegenerative disorders and Alzheimer's disease induced byAlCl3 on the pyramidal cells in cerebral cortex of male albino rats. 24 Adult male albino rats were divided into four groups 6 for each, control, (300mg/kg p.o) AlCl3 treated group for a month, (300mg/kg p.o.)AlCl3 plus (0.5gm/kg p. o) aqueous seed coriander extract treated group for a month and (0.5gm/kg p.o.) aqueous seed coriander extract treated group after stopping aluminum chloride treatment each for a month. Specimens from cerebral cortex were processed for haematoxylin and eosin, toluidine blue and Nauta stains. Aluminum chloride treatment showed dilatation of blood capillaries and presence of many shrunken pyramidal cells, the cells are pale and chromatolytic, the fibers appear detached and irregular in thickness. Aluminum chloride and coriander treated group restore the pyramidal cells of the cerebral cortex to normal. The treatment with coriander for a month after stopping AlCl3 treatment restores the pyramidal cells to nearly normal. In conclusion coriander eed s aqueous extract showing protection and an improvement in therapeutic action on pyramidal cells in cerebral cortex against neurodegenerative disorders and Alzheimer' disease induced by aluminum chloride treatment. [Researcher. 2010;2(8):24-33]. (ISSN: 1553-9865).